The erythrocyte sedimentation rate (ESR) test checks for inflammation in the body. It is usually used along with other tests, as it doesn't indicate what is causing the inflammation, nor where it is.
What is being tested?
Inflammation causes red blood cells to stick to each other and form clumps. These clumps are heavier than normal individual red blood cells.
In an ESR, blood is put into a test tube and allowed to settle. If there is inflammation, the red blood cells will clump together and fall quickly to the bottom of the tube. If there is no inflammation, the red blood cells will settle more slowly. Either way, there is a column of clear liquid (plasma, which has no red blood cells) at the top of the tube.
The ESR measures the height of the column of plasma after 1 hour. A low reading means not many cells have settled, which suggests no inflammation. A high reading means a lot of cells have settled, which suggest inflammation.
Why would I need this test?
You might need an ESR test if your doctor suspects that you have an infection or an illness related to inflammation. As ESR is not specific, other tests might be needed to identify the location and cause of the inflammation or infection.
ESR is particularly useful in detecting two specific illnesses: giant cell arteritis and polymyalgia rheumatica.
How to prepare for this test
No preparation is needed for this test.
Understanding your results
A high ESR can indicate inflammation somewhere in the body, but it does not say where or indicate the specific cause.
The ESR also increases with age, pregnancy and in those with anaemia.
It is important to speak with your doctor about your results.
About ESR testing
See Pathology Tests Explained for more information about the ESR test.
About blood testing
Visit healthdirect‘s ’Guide to blood testing’ to learn more about blood tests in general with information such as:
- what to consider before having a blood test
- what happens during a blood test
- results accuracy
- blood tests cost
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Last reviewed: August 2020