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Sickle cell anaemia

5-minute read

Key facts

  • Sickle cell disease is a genetic disorder.
  • People with sickle cell disease develop sickle cell anaemia.
  • Sickle cell anaemia causes your red blood cells to be sickle shaped.
  • Ongoing treatment helps you manage pain and reduces your chances of infection.

What is sickle cell anaemia?

Sickle cell anaemia is one of a group of disorders known as sickle cell disease.

Sickle cell disease

Sickle cell disease is a group of blood disorders that affect your haemoglobin. Haemoglobin is in your red blood cells. It’s responsible for carrying oxygen around your body.

Sickle cell disease is an inherited condition. If you have sickle cell anaemia, both of your parents must have given you a faulty gene.

Your parents may not:

  • have sickle cell anaemia
  • know that they carry the gene for sickle cell anaemia

The genes for sickle cell disease are most often found in people with any of the following ethnic backgrounds:

  • African
  • Middle Eastern
  • Southern European
  • Indian
  • Pakistani
  • South American
  • Caribbean

What are the symptoms of sickle cell anaemia?

People with sickle cell anaemia may:

  • be tired
  • have pale skin

Children with sickle cell anaemia may have delayed growth and development.

The sickle (crescent) shape of the red blood cells can cause them to get caught in your small blood vessels. This can cause:

What causes sickle cell anaemia?

Usually, your red blood cells are round. This means that they can bend to go through small blood vessels and pop back into their normal shape.

In people with sickle cell anaemia, the red blood cells form a crescent, or sickle, shape.

Usually, red blood cells live for 120 days before being replaced. But sickle cells last only 10 to 20 days. This causes a shortage of red blood cells (anaemia).

How is sickle cell anaemia diagnosed?

Sickle cell anaemia is diagnosed by blood tests. Special blood tests can tell if you carry the sickle cell gene.

If you carry the gene for sickle cell disease, your doctor may suggest screening your immediate family. That is your: parents, children, brothers and sisters. This is because they have a 1 in 2 chance (50%) of carrying the sickle cell disease gene.

How is sickle cell anaemia treated?

Your doctor might give you medicines to help reduce your symptoms. There is strong evidence for the use of hydroxyurea to treat sickle cell disease.

Blood transfusions can be used to treat the complications of sickle cell disease.

Bone marrow transplants can cure sickle cell disease. However, there are some problems with this treatment option:

  • lack of suitable bone marrow donors
  • transplant rejection
  • long term problems with your heart, kidneys and eyes

Some researchers are now looking at gene therapy to treat sickle cell disease.

You can use some self-management strategies to reduce the effects of sickle cell disease. These include:

  • drinking plenty of fluids
  • eating a healthy diet
  • preventing infections by being fully vaccinated and sometimes taking daily antibiotics if needed
  • avoiding extreme temperatures
  • avoiding over-activity
  • using pain relief medicines (for example, paracetamol or ibuprofen) to manage your pain

Can sickle cell anaemia be prevented?

Sickle cell disease is inherited so can’t be prevented.

Sickle cell disease isn’t contagious (you can’t catch it).

Living with sickle cell anaemia

It’s important to try to and stay as healthy as possible. Take steps to:

  • manage your pain
  • avoid infections

If you want to get pregnant, you may want to think about genetic testing or genetic counselling.

If you need surgery, it’s important to tell your surgeon and anaesthetist about your sickle cell anaemia. General anaesthetics can cause problems, such as pain episodes.

Resources and support

For support with sickle cell anaemia, visit the Thalassaemia and Sickle Cell Australia website.

You can also find information on sickle cell anaemia in languages other than English on the Thalassaemia and Sickle Cell Australia website.

Visit our genetic disorders guide to learn more about genetic disorders.

You can also call the healthdirect helpline on 1800 022 222 (known as NURSE-ON-CALL in Victoria). A registered nurse is available to talk with 24 hours a day, 7 days a week.

Learn more here about the development and quality assurance of healthdirect content.

Last reviewed: November 2022


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