Healthdirect Free Australian health advice you can count on.

Medical problem? Call 1800 022 222. If you need urgent medical help, call triple zero immediately

healthdirect Australia is a free service where you can talk to a nurse or doctor who can help you know what to do.

beginning of content

Peripheral vascular disease treament

5-minute read

There are two main types of treatment used in the management of peripheral vascular disease(PVD):

  • making lifestyle changes to improve symptoms and reduce your risk of developing a more serious cardiovascular disease (CVD), such as coronary heart disease
  • taking medicine to address the underlying cause of PVD and reduce your risk of developing another cardiovascular disease. For example, a statin can be used to lower your cholesterol levels

Surgery may be used as a last resort. These treatment types are discussed in more depth below.

Lifestyle changes

The two most important lifestyle changes you can make if you are diagnosed with PVD are outlined below:

Smoking cessation

If you currently smoke, stop.

  • It is recommended that you use an anti-smoking treatment such as nicotine replacement therapy (NRT) or bupropion (a medicine used to reduce cravings for cigarettes). People who use these treatments have a much greater success rate in permanently quitting than people who try to quit using willpower alone.
  • If you want to quit smoking, it is a good idea to see your doctor first. They can provide help and advice about quitting, and can refer you to a Stop Smoking support service. Quit Now can provide more information through their website or by calling their information line on 13 7848.


There is a lot of high-quality evidence showing that taking part in regular exercise helps to reduce the severity and frequency of PVD symptoms, while at the same time reducing the risk of developing another cardiovascular disease.

Research has found that after six months of regular exercise, a person can:

  • walk for longer and further before experiencing pain
  • see an improvement in their ABI score (a test done to assess the circulation in your lower legs)

The preferred exercise is walking. It is normally recommended that you walk as far and as long as you can before the symptoms of pain become intolerable. Once this happens, rest until the pain goes and begin walking again until the pain returns. Keep using this 'stop-start' method until you have spent at least 30 minutes walking.

You will probably find the exercise course challenging, as the frequent episodes of pain can be upsetting and off-putting. But if you persevere, you should gradually notice a marked improvement in your symptoms and you will begin to go longer and longer without experiencing any pain.


Different medicines can be used to treat the underlying causes of PVD while reducing your risk of further developing CVD.

Some people may only need to take one or two of the medicines discussed below, while others may need to take all of them.


If blood tests show that your levels of LDL cholesterol ('bad cholesterol') are high, you will be prescribed a type of medicine called a 'statin'.

Statins work by helping to reduce the production of LDL cholesterol by your liver.


Antihypertensives are a group of medicines used to treat high blood pressure.

It is likely you will be prescribed an antihypertensive drug if your blood pressure is higher than 140/90mmHg if you do not have diabetes, or 130/80mmHg if you do have diabetes.

A widely used type of antihypertensive is an angiotensin-converting enzyme (ACE) inhibitor.

ACE inhibitors block the actions of some of the hormones that help to regulate blood pressure. They help to reduce the amount of water in your blood and widen your arteries, which will both decrease your blood pressure.

A medicine that works in a similar way to ACE inhibitors, known as an 'angiotensin-2 receptor antagonist', may also be recommended.

ACE inhibitors and angiotensin-2 receptor antagonists can cause unpredictable effects if taken with other medicines, including some over-the-counter ones, so check with your doctor or pharmacist before taking anything in combination with this medicine.


One of the biggest potential dangers if you have atherosclerosis is a piece of fatty deposit (plaque) breaking off from your artery wall. This can cause a blood clot to develop at the site of the broken plaque.

If a blood clot develops inside an artery that supplies the heart with blood (a coronary artery), it can trigger a heart attack. Similarly, if a blood clot develops inside any of the blood vessels going to the brain, it can trigger a stroke.

You will probably be prescribed an antiplatelet medicine to reduce your risk of blood clots. This medicine reduces the ability of platelets (tiny blood cells) to stick together, so if a plaque does break apart, you have a lower chance of a blood clot developing.

Low-dose aspirin (usually 75mg a day) is usually recommended.

Common side effects of aspirin include:

  • irritation of the stomach or bowel
  • indigestion
  • nausea (feeling sick)

If you are unable to take aspirin (for example, if you have a history of stomach ulcers or you are allergic to aspirin), an alternative antiplatelet called 'clopidogrel' may be used.


Cilostazol reduces the ability of the blood to clot, while causing the arteries in the legs to expand, which should both help improve the blood supply to your legs.

Cilostazol is not recommended if you are pregnant or breastfeeding.


Bypass grafting - this surgery is done if the blood flow in your leg is obstructed. In this procedure, a graft (blood vessel taken from another part of your body or an artificial tube) is placed to bypass the blood flow around the blockage.

Angioplasty and stenting - angioplasty is a procedure done to restore blood flow through a blocked artery. It involves passage of a catheter with a deflated balloon at its tip into a blocked artery. The balloon is then inflated in order to displace the plaque outwards. This restores the blood flow by widening the artery. In addition, a stent may be placed in the artery to keep it open after angioplasty is done.

Learn more here about the development and quality assurance of healthdirect content.

Last reviewed: January 2018

Back To Top

Need more information?

These trusted information partners have more on this topic.

Healthdirect 24hr 7 days a week hotline

24 hour health advice you can count on

1800 022 222

Government Accredited with over 140 information partners

We are a government-funded service, providing quality, approved health information and advice

Australian Government, health department logo ACT Government logo New South Wales government, health department logo Northen Territory Government logo Government of South Australia, health department logo Tasmanian government logo Government of Western Australia, health department logo