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Acromegaly is a disorder that mostly affects people in middle age, causing certain parts of the body to grow larger. It can be treated effectively, especially if diagnosed early.

What is acromegaly?

Acromegaly is a disorder that affects adults and is caused by overproduction of growth hormone. Growth hormone (also called human growth hormone, GH or HGH) controls the normal growth of the body’s tissues, organs and bones, as well as helping control its metabolism.

A similar condition, known as gigantism, can occur in children and can make them grow very tall. Adults with too much growth hormone don’t grow exceptionally tall because once they have gone through puberty, their long bones don’t grow any longer.

Causes of acromegaly

Acromegaly is caused by the pituitary gland in the brain producing too much growth hormone, usually because of a benign tumour in the gland. Pituitary tumours (also known as pituitary adenomas) tend to grow very slowly.

Very rarely, acromegaly can be caused by hormone-producing tumours in other parts of the body, such as the lungs, pancreas or adrenal glands.

Symptoms of acromegaly

The main signs of acromegaly are:

  • changes to facial features, such as a broadening nose, enlarging jaw and more widely spaced teeth
  • enlarged lips or tongue
  • enlarged hands and feet

A pituitary tumour can also cause a range of other problems, such as:

If you have symptoms of acromegaly, see your doctor for advice.

Diagnosis of acromegaly

Because the changes happen slowly, it can take a while for you to notice them and to get medical advice. But getting an early diagnosis is important since it can lower your chances of developing problems such as diabetes or heart disease.

Tests used to diagnose acromegaly include:

  • blood tests – to measure the level of hormones
  • oral glucose tolerance test – to see how growth hormone levels change when blood sugar level is increased
  • an MRI or CT scan – to see the pituitary gland
  • x-rays of the skull and jaw – to check bone thickness

Treatment of acromegaly

Treatments can reduce your production of growth hormone to a normal level and help control symptoms. The options for treatment are:

  • surgery – to remove a pituitary tumour
  • radiotherapy – to shrink a pituitary tumour
  • drug therapy – to counter the effects of too much growth hormone

These treatments can be used on their own or in any combination.

Living with acromegaly

Living with acromegaly can be a stressful experience, particularly while you are waiting for a diagnosis, treatment or for your symptoms to improve. However, treatment is often successful. While it might not be possible to reverse all changes to the shape and size of your bones, many people notice their bodies gradually returning to normal over time.

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Last reviewed: February 2018

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