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Allergies and allergic reactions are common. About 1 in 3 Australians have allergies at some point in their lives. Usually, the symptoms of allergic reactions can be easily and effectively treated using a group of medicines called antihistamines.

If you think someone is having a serious allergic reaction, or anaphylaxis, call triple zero (000). Do not use antihistamines as they will work too slowly. Anaphylaxis should be treated with a shot of adrenaline into a muscle.

Allergies and histamine

Your body can become sensitive to things around you, such as foods, plants, animals and medicines. If you are allergic to something, it is called an allergen.

When the body is exposed to allergens it releases histamine, a chemical that is an important part of your body’s immune response. Histamine makes you sneeze, makes your nose run, and makes your eyes and skin itch, become red and swell up. In a way, it is trying to get you to sneeze out or scratch away the allergen.

Treating allergies and allergic reactions with antihistamines

Antihistamines are medicines that act by blocking the body's response to histamine in different parts of the body. This reduces the severity of the reaction and eases the symptoms of allergy.

Antihistamines are commonly used to treat a number of conditions related to allergies and hypersensitivities such as:

Some antihistamines block histamine in the stomach and reduce acid production, and are therefore used to treat heartburn and indigestion. These antihistamines are different from those used to treat allergies.

Oral antihistamines can be used to treat all of the symptoms of an allergic reaction. Others come as eye drops or nasal sprays, for treating specific symptoms only. Some oral antihistamines may have a sedative effect, but others are non-sedating or non-drowsy.

Side effects of antihistamines

Some people get side effects from oral antihistamines such as:

  • tiredness
  • drowsiness
  • headache
  • dry mouth
  • upset stomach

They usually don't last long.

If you use antihistamines you should be careful when operating machinery, such as driving a car. Even non-sedating antihistamines can make some people drowsy.

You should talk to a pharmacist or doctor before taking an antihistamine if you:

People with porphyria should talk to their doctor or pharmacist before taking antihistamines.

If you have any questions or concerns about antihistamines, please talk to your doctor or pharmacist.

Learn more here about the development and quality assurance of healthdirect content.

Last reviewed: August 2021

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