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Brand name: Leucovorin Calcium (DBL) TM

Active ingredients: folinic acid

What it is used for

Neutralising the immediate toxic effects of folic acid antagonists, eg methotrexate. Treatment of megaloblastic anaemias due to folic acid deficiency, eg in sprue, malnutrition, pregnancy, infancy, liver disease and malabsorption syndromes. Folinic acid rescue, ie using calcium folinate in conjunction with folic acid antagonists, eg methotrexate, to minimise systemic toxicity. INDICATIONS AS AT 13 JAN 05 : Leucovorin Calcium has shown good results in the treatment of certain megaloblastic anaemias resulting from folic acid deficiency. This mainly occurs in infants, during pregnancy, in malabsorption syndromes, liver diseases, sprue and malnutrition. It is not more effective than folic acid for these conditions. Leucovorin Calcium has also shown good results in reducing the toxicity and circumventing the effect of folic acid antagonists, if therapeutically desired.

How to take it

You should seek medical advice in relation to medicines and use only as directed by a healthcare professional.

  • The way to take this medicine: Intravenous
  • Store at 2 to 8 degrees Celsius
  • Protect from Light
  • Lifetime is 2 Years.

Always read the label. If symptoms persist see your healthcare professional.

Visual appearance

Clear, straw to pale yellow coloured solution, free from visible particulate matter.

Do I need a prescription?

This medicine is available from a pharmacist and requires a prescription. It is Schedule 4 : Prescription Only Medicine.

Pregnant or planning a pregnancy?

For the active ingredient folinic acid

This medicine is generally considered safe during pregnancy if taken as directed. During pregnancy, you should discuss your medicine use with your doctor or pharmacist.

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For side effects, taking other medicines and more

Download consumer medicine information leaflet (pdf)


The information about this medicine comes from trusted sources.

  • Therapeutic Good's Administration (TGA)
  • Pharmaceutical Benefits Scheme (PBS)
  • GuildLink
  • DrugBank

healthdirect medicines information is not intended for use in an emergency. If you are suffering an acute illness, overdose, or emergency condition, call triple zero (000) and ask for an ambulance.

Reasonable care has been taken to provide accurate information at the time of creation. This information is not intended to substitute medical advice, diagnosis or treatment and should not be exclusively relied on to manage or diagnose a medical condition. Please refer to our terms and conditions.

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