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Brand name: Leucovorin Calcium (DBL) TM

Active ingredients: folinic acid

What it is used for

Neutralising the immediate toxic effects of folic acid antagonists, eg methotrexate. Treatment of megaloblastic anaemias due to folic acid deficiency, eg in sprue, malnutrition, pregnancy, infancy, liver disease and malabsorption syndromes. Folinic acid rescue, ie using calcium folinate in conjunction with folic acid antagonists, eg methotrexate, to minimise systemic toxicity. INDICATIONS AS AT 13 JAN 05 : Leucovorin Calcium has shown good results in the treatment of certain megaloblastic anaemias resulting from folic acid deficiency. This mainly occurs in infants, during pregnancy, in malabsorption syndromes, liver diseases, sprue and malnutrition. It is not more effective than folic acid for these conditions. Leucovorin Calcium has also shown good results in reducing the toxicity and circumventing the effect of folic acid antagonists, if therapeutically desired.

How to take it

The way to take this medicine is: Intravenous. This medicine or fluids is given through a needle or tube (catheter) inserted into a vein.

  • Store at 2 to 8 degrees Celsius
  • Protect from Light
  • Shelf lifetime is 2 Years.

You should seek medical advice in relation to medicines and use only as directed by a healthcare professional.

Always read the label. If symptoms persist see your healthcare professional.

Visual appearance

Clear, straw to pale yellow coloured solution, free from visible particulate matter.

Do I need a prescription?

This medicine is available from a pharmacist and requires a prescription. It is Schedule 4 : Prescription Only Medicine.

Is this medicine subsidised?

This medicine was verified as being available on the PBS (Pharmaceutical Benefits Scheme) on April 1, 2019. To learn more about this subsidy, visit the Pharmaceutical Benefits Scheme (PBS) website.

Pregnant or planning a pregnancy?

For the active ingredient folinic acid

This medicine is generally considered safe during pregnancy if taken as directed. During pregnancy, you should discuss your medicine use with your doctor or pharmacist.

Download leaflet

For side effects, taking other medicines and more

Download consumer medicine information leaflet (pdf) from the Therapeutic Goods Administration (TGA) website

Reporting side effects

You can help ensure medicines are safe by reporting the side effects you experience.

You can report side effects to your doctor, or directly at

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