Active ingredients: colecalciferol
What it is used for
 The working group of the Australian and New Zealand Bone and Mineral Society, Endocrine Society of Australia and Osteoporosis Australia state that a significant number of Australians are deficient in vitamin D.  Vitamin D3 is known to be pleiotropic, meaning it influences the expression of numerous/many genes throughout many/a range of systems and organs of the body.  Vitamin D receptors (VDR) are present in a wide variety of cells in numerous/many systems and most organs in the body (eg: heart, immune system, central and peripheral nervous systems, skeleton, brain, kidneys, skin, prostate and breast).  Older individuals/people may have an increased requirement for vitamin D3. [5a] The bodys ability to metabolise vitamin D to its active form may decline with age. [5b] Aging decreases the capacity/ability of the skin to produce vitamin D3 (because the concentration of 7-dehydrocholesterol in the skin decreases with age). [5c] Evidence suggests that by the age of 70yrs, the skins ability to produce vitamin D3 is reduced by approximately 75% compared to younger adults.  Vitamin D is required for healthy cell development, differentiation and maturation.  Adequate vitamin D is important for the maintenance of a normal healthy immune system.  1,25(OH)2D3 (calcitriol) interacts with immune cells such as monocyte-macrophages, antigen presenting cells, dendritic cells and lymphocytes and induces their differentiation. [9a] Vitamin D enhances/supports/improves the ability of the small intestine to absorb calcium from the diet. [9b] Adequate levels of Vitamin D are necessary for the maintenance of normal healthy calcium metabolism. [9c] Vitamin D is important/necessary/essential for the efficient utilisation of calcium by the body. [9d] Vitamin D is important for the maintenance of strong healthy bones. [10a] Vitamin D plays an important role in the development, growth and mineralization/maintenance of a healthy skeleton. [10b] Vitamin D assists in maintaining healthy plasma calcium and phosphorus concentrations so that skeletal mineralization occurs.  Vitamin D is required for the normal healthy growth of growing childrens bones.  Vitamin D3 supplementation may help to reduce the risk of falls in older adults/individuals which may help reduce the incidence/risk of fractures. The mechanism is not yet completely understood, however evidence suggests that as well as having a positive influence on calcium absorption, Vitamin D3 may also have a positive influence on postural and/or dynamic balance.  Vitamin D3 assists in maintaining healthy skeletal and cardiac muscles possibly due to its role in muscle cell growth and differentiation.  Prostate cells have vitamin D receptors and vitamin D3 is involved in healthy prostate cell metabolism/differentiation/maturation.  Vitamin D may provide nutritional support for the maintenance of a healthy cardiovascular system and cardiac/heart muscle.  In vitro and animal studies suggest that vitamin D3 and the vitamin D receptor VDR are involved in the (inhibitory) regulation of renin transcription, indicating/proposing a possible inverse relationship between vitamin D3 levels and renin production.  Adequate levels of vitamin D in pregnancy are/have been associated/linked with healthy/favourable pregnancy outcomes (foetal birth weight, foetal skeletal growth and limb length). [18[ Vitamin D receptor and vitamin D metabolising enzymes are found in the testis, sperm and the male reproductive tract and may have a role in male fertility (including spermatogenesis, sperm maturation and sperm fertilising ability).
How to take it
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- The way to take this medicine: Oral
Always read the label. If symptoms persist see your healthcare professional.
Do I need a prescription?
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Reporting side effects
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