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Brand name: Endoxan TM

Active ingredients: cyclophosphamide

What it is used for

Frequently responsive myeloproliferative and lymphoproliferative disorders: Malignant lymphomas including Hodgkins (Stages III and IV, Peter's Staging System*) and non-Hodgkins lymphomas; multiple myeloma; leukaemias; mycosis fungoides (advanced disease). *Modified as the International Staging Classification for Hodgkin's Disease in 'Report of the Committee on the Staging of Hodgkin's Disease'. Cancer Res 26: 1310, 1966. Stage I. Disease limited to one anatomic region (Stage I) or two contiguous anatomic regions (Stage I2) on the same side of the diaphragm. Stage II. Disease in more than two anatomic regions or two contiguous regions on the same side of the diaphragm. Stage III. Disease on both sides of the diaphragm but not extending beyond the involvement of lymph nodes, spleen and/or Waldeyer's ring. Stage IV. Involvement of the bone marrow, lung parenchyma, pleura, liver, bone, skin, kidneys, gastrointestinal tract, or in any tissue or organ in addition to lymph nodes, spleen or Waldeyer's ring. All stages are subclassified as A or B to indicate the absence or presence, respectively, of systemic symptoms. Frequently responsive solid malignancies: Neuroblastoma (patients with disseminated disease); adenocarcinoma of the ovary, retinoblastoma. Infrequently responsive malignancies: Carcinoma of the breast; malignant neoplasms of the lung. Immunosuppressive properties: Cyclophosphamide has also been used in the treatment of autoimmune diseases and immunopathies of unspecified type (i.e. Wegener's granulomatosis) when these diseases have been resistant to conventional first and second line of treatment, and for the prevention of transplant rejection. Cyclophosphamide can be recommended for use in treatment of nonmalignancies only when in the opinion of the physician the benefits to the patient outweigh the risk of treatment with cyclophosphamide.

How to take it

The way to take this medicine is: Intravenous. This medicine or fluids is given through a needle or tube (catheter) inserted into a vein.

  • Store below 25 degrees Celsius
  • Protect from Light
  • Shelf lifetime is 3 Years.

You should seek medical advice in relation to medicines and use only as directed by a healthcare professional.

Always read the label. If symptoms persist see your healthcare professional.

Visual appearance

White crystalline substance

Do I need a prescription?

This medicine is available from a pharmacist and requires a prescription. It is Schedule 4 : Prescription Only Medicine.

Pregnant or planning a pregnancy?

For the active ingredient cyclophosphamide

You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy.

Download leaflet

For side effects, taking other medicines and more

Download consumer medicine information leaflet (pdf) from the Therapeutic Goods Administration (TGA) website

Reporting side effects

You can help ensure medicines are safe by reporting the side effects you experience.

You can report side effects to your doctor, or directly at

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