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Creutzfeldt-Jakob disease

Creutzfeldt-Jakob disease (CJD) is a very rare brain disorder that causes dementia. While there is no treatment or cure for CJD at the moment, medical research is continuing.

What is Creutzfeldt-Jakob disease?

CJD is a very rare and serious disease. It causes the brain to degenerate and become spongy, leading to dementia and death.

It happens when infectious particles called prions damage brain cells.

CJD belongs to a group of rare diseases known as transmissible spongiform encephalopathies (TSE) or prion diseases.

Causes of Creutzfeldt-Jakob disease

There are a few different ways to develop CJD: 

  • Sporadic CJD occurs for no obvious cause.
  • Genetic or familial CJD is inherited.
  • Medically acquired CJD is spread accidentally during brain or cornea surgery if medical staff use contaminated instruments. Some people have contracted CJD after receiving transplants of diseased human growth hormone or tissue or after blood tranfusions.
  • Variant CJD is the human form of a disease called bovine spongiform encephalopathy (BSE) that occurs in cattle and is often referred to as ‘mad cow disease’. People who ate meat infected with BSE contracted variant CJD in the United Kingdom during the 1980s and 1990s. Neither form of the disease has been found in Australia. Although variant CJD occurs in humans and BSE occurs in cattle, there is often confusion between variant CJD and mad cow disease.

Creutzfeldt-Jakob disease does not spread from person to person through kissing, sneezing, coughing or body contact.

Symptoms of Creutzfeldt-Jakob disease

CJD takes years to show up, and the first symptoms are vague. Early signs and symptoms of CJD include:

  • changes in personality and behaviour
  • problems with memory
  • problems with thinking
  • problems with speaking and swallowing
  • double vision or blindness
  • depression
  • muscle spasms.

Most people with CJD decline quickly towards the end of their life.

Diagnosis of Creutzfeldt-Jakob disease

Creutzfeldt-Jakob disease can be confirmed only by doing special tests on brain tissue. Often these tests are done during an autopsy, which is performed after the person affected dies.

Treatment of Creutzfeldt-Jakob disease

There is no treatment or cure for CJD. However, research for a cure is continuing.

Prevention of Creutzfeldt-Jakob disease

There is no way to prevent sporadic CJD. To assess your risk of genetic CJD, you could talk to a genetics counsellor, especially if there are people in your family with diseases that affect the brain.

Medically acquired CJD is very rare in Australia. People who lived in the UK for more than 6 months between 1980 and 1996 aren’t allowed to donate blood, because of the slight risk that they might have picked up the infection.

Last reviewed: March 2016

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Creutzfeldt-Jakob disease information

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Creutzfeldt-Jakob disease - myDr.com.au

Creutzfeldt–Jakob disease (CJD) is a fatal, degenerative brain disorder that causes rapidly progressive dementia and loss of muscle control. It is a rare disease, affecting 1–2 people in every million in Australia.

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Creutzfeldt-Jakob disease (CJD) is a rare brain disease that is caused by abnormal brain proteins called prions. Classical CJD usually occurs by chance. Variant CJD, which is linked to consumption of contaminated meat products, does not occur in Australia.

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Creutzfeldt-Jakob disease and variant Creutzfeldt-Jakob disease - including symptoms, treatment and prevention :: SA Health

These are progressive fatal infections of the brain caused by an infectious protein particle called a prion. These diseases are some of a group of brain infections known as Transmissible Spongiform Encephalopathies (TSE).

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This page contains information on the relation between human pituitary hormone treatment and Creutzfeldt-Jakob disease (CJD) as well as Government's initiatives for the control and prevention of CJD.

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This page contains questions and answers about bovine spongiform encephalopathy (BSE) in animals and its links with variant Creutzfeldt-Jakob disease (vCJD) in humans.

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Bovine Spongiform Encephalopathy (BSE) in animals

Entry to the Department's web pages on bovine spongiform encephalopathy (BSE) in animals and its links to variant Creutzfeldt-Jakob disease (vCJD) in humans.

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Australia's measures to protect human health

This page contains details of measures taken by the Australian Government to protect the health of the Australian public from bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD).

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