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Brand name: Mandol TM

Active ingredients: cefamandole

What it is used for

Cephamandole nafate is indicated for the treatment of the following infections when sue to susceptible organisms (See PHARMACOLOCY: ANTI-BACTERIAL ACTIVITY). (1) Respiratory tract infections. (2) Genito-urinary tract infections. (3) Peritonitis and other intra-abdominal and intra-pelvic infections. (4) Septicaemia. (5) Skin ans soft-tissue infections. (6) Bone and joint infections. Note: Concentrations of cephamandole in the CSF are considerably lower than in the plasma, its use in the treatment of bacterial meningitis and brain abscess is therefore not advised. INDICATIONS AS AT 30 June 94: MANDOL is indicated for the treatment of serious infections of the respiratory tract, genitourinary tract, skin and soft tissue, bones and joints, septicaemia, gall bladder and peritoneum when due to susceptible strains of the above mentioned organisms. Concentrations of MANDOL in the CSF are considerably lower than in the plasma; use in the treatment of meningitis and brain abscess is therefore not advised. Specimens for bacteriologic cultures should be obtained in order to isolate and identify causative organisms and to determine their susceptibilities to MANDOL. Therapy may be instituted before results of susceptibility studies are known; however, once these results become available, the antibiotic treatment should be adjusted accordingly. In certain cases of confirmed or suspected gram-positive or gram-negative sepsis or in patients with other serious infections in which the causative organism has not been identified, MANDOL may be given concomitantly with an aminoglycoside, eg. tobramycin (see PRECAUTIONS). The recommended doses of both antibiotics may be given, depending on the severity of infection and the condition of the patient. The patient's renal function should be carefully monitored, especially if higher dosages of the antibiotics are to be administered. Antibiotic therapy of beta-haemolytic streptococcal infections should continue for at least 10 days. Preventative therapy The administration of MANDOL preoperatively, intraoperatively and postoperatively may reduce the incidence of certain postoperative infections in patients undergoing surgical procedures that are classified as contaminated or potentially contaminated (eg. gastrointestinal surgery, caesarean section, vaginal hysterectomy or cholecystectomy in high-risk patients such as those with acute cholecystitis, obstructive jaundice or common-bile-duct stones). In major surgery in which the risk of postoperative infection is low but serious (cardiovascular surgery, neurosurgery or prosthetic arthroplasty), MANDOL may be effective in preventing such an infection. If signs of infection occur, specimens for culture should be obtained for identification of the causative organism so that appropriate antibiotic therapy may be instituted.

How to take it

The way to take this medicine is: Intramuscular. This medicine is given through a needle inserted into the muscle beneath the skin.

  • Store below 25 degrees Celsius
  • Shelf lifetime is 3 Years.

You should seek medical advice in relation to medicines and use only as directed by a healthcare professional.

Always read the label. If symptoms persist see your healthcare professional.

Visual appearance

A white to off-white crystalline powder

Do I need a prescription?

This medicine is available from a pharmacist and requires a prescription. It is Schedule 4 : Prescription Only Medicine.

Pregnant or planning a pregnancy?

For the active ingredient cefamandole

You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy.

Reporting side effects

You can help ensure medicines are safe by reporting the side effects you experience.

You can report side effects to your doctor, or directly at www.tga.gov.au/reporting-problems

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