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Brand name: Disodium Edetate 3 g plus Sodium Ascorbate 5 g (Biological Therapies)

Disodium Edetate 3 g plus Sodium Ascorbate 5 g (Biological Therapies) is a medicine containing the active ingredient(s) edetic acid + ascorbic acid. On this page you will find out more about Disodium Edetate 3 g plus Sodium Ascorbate 5 g (Biological Therapies), including side effects, age restrictions, food interactions and whether the medicine is subsidised by the government on the pharmaceutical benefits scheme (PBS)

You should seek medical advice in relation to medicines and use only as directed by a healthcare professional. Always read the label. If symptoms persist see your healthcare professional. healthdirect medicines information is not intended for use in an emergency. If you are suffering an acute illness, overdose, or emergency condition, call triple zero (000) and ask for an ambulance.

Reasonable care has been taken to provide accurate information at the time of creation. This information is not intended to substitute medical advice, diagnosis or treatment and should not be exclusively relied on to manage or diagnose a medical condition. Please refer to our terms and conditions.

Active ingredient in this medicine: edetic acid + ascorbic acid

Information for medicine and pack size:
Disodium Edetate 3 g plus Sodium Ascorbate 5 g (Biological Therapies) concentrated injection, 50 mL vial

Consumer Medicine Information leaflet:

This leaflet may also be found inside the medicine package. It contains information on side effects, age restrictions and other useful data.

Read leaflet

What this medicine is for

1. Disodium Edetate is particularly effective in treating lead accumulation and lead poisoning. This is especially so where there is a concomitant hypercalcaemic problem (refer "Indications (2)"). However it must be noted that Disodium Edetate is equally effective with Calcium Disodium Edetate in removing heavy metals, even in the absence of hypercalcaemia. For patients with elevated serum calcium or hypermobility of their body pools of calcium where there may be transiently or prolonged raised serum calcium (see "Indications (2)"), the EDTA of choice for removing heavy metals may be Disodium Edetate. There are no recognised safe limits for lead intoxication. Lead poisoning may occur by ingestion or inhalation of lead dust or fumes. Poisoning is manifested by a metallic taste, anorexia, irritability, apathy, abdominal colic, vomiting, diarrhoea, constipation, headache, leg cramps, black stools, oliguria, stupor, convulsions, palsies and coma. Chronic lead poisoning causes variable involvement of the Central Nervous System, the blood forming organs and the gastrointestinal tract. Diagnostic laboratory tests include blood lead, hair analysis, urine coproporphyrin, urine delta-aminolevulinic acid, x-ray of abdomen and x-ray of long bones. Comparing the results of a 12-hour urine collection, pre-EDTA therapy, with the results of a 12-hour urine collection, during/post initial EDTA chelation, should confirm the early excretory surge of lead. As long as significant quantities of lead remain in the bone, any intercurrent illness which causes demineralisation can cause mobilisation of toxic quantities of lead into soft tissues and exacerbate plumbism. 2. Disodium Edetate may be used to temporarily reduce serum Calcium in patients with hypercalcaemia. Transient or prolonged hypercalcaemia may exceed the solubility product of calcium and result in tissue damage. Increased plasma calcium may give rise to renal lithiasis or acute pancreatitis. Calcium may also precipitate in the eyes (band keratopathy) and in soft tissues around the joints. There are many primary and secondary causes of transient and prolonged hypercalcaemia, which include the following: i) The injection of Calcium Disodium EDTA may itself give rise to a transient hypercalcaemia. ii) IMMOBILISATION, which may be associated with all sorts of conditions. For example, in Paget's Disease it is sometimes warranted to supplement with calcium unless there is chronic immobilisation (greater than 3 days immobilisation in bed may precipitate a hypercalcaemia), in which case patients should be placed on a calcium restricted diet. iii) Increased ingestion and uptake of calcium, as in dairy foods or calcium supplements such as calcium citrate. iv) Increased ingestion and uptake of vitamin D. v) Hypervitaminosis A. vi) Osteoarthritis, Rheumatoid Arthritis, Hyperthyroidism, Hyperparathyroidism, Malignancies, Multiple Myeloma, prolonged use of Heparin, Immunosuppressant Drugs, Acromegaly. 3. Disodium Edetate may be valuable in the management of severe digitalis arrhythmias, when a rapid response is required. 4. Disodium Edetate is useful in helping to eliminate some radioactive metals, including Calcium, Strontium, Radium, Cobalt and the very toxic Plutonium.

Table of characteristics
Table of characteristics
Active ingredient
Visual appearance Clear and colourless to straw coloured solution.
Dosage Form Injection, concentrated
Route of administration Intravenous
Medicine schedule
1 X 50mL vial: Prescription Only Medicine, or Prescription Animal Remedy

There is one type of pack available.

Pack type 1
Pack type 1
Type Vial
Storage temperature Store below 25 degrees Celsius
Storage conditions No information available
Life time 2 Years
We were unable to verify that this medicine is available on the PBS (Pharmaceutical Benefits Scheme). Please consult your pharmacist if you need further information

The PBS provides a list of government subsidised medicines available to be dispensed to patients. Further information can be found on the Pharmaceutical Benefits Scheme website.

Go to PBS site

Is this medication banned in sport?

Check if you can use your medicine whilst playing sport. Search the Australian Sports Anti-Doping Authority (ASADA) database that provides information about the prohibited status of specific medications and/or the active ingredient based on the current World Anti-Doping Agency (WADA) Prohibited List.

Go to ASADA site

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