Healthdirect Free Australian health advice you can count on.

Medical problem? Call 1800 022 222. If you need urgent medical help, call triple zero immediately

healthdirect Australia is a free service where you can talk to a nurse or doctor who can help you know what to do.

beginning of content

Brand name: Solu-Cortef Act-O-Vial TM

Listen to the Pronunciation:

Active ingredients: hydrocortisone sodium succinate

What it is used for

INDICATIONS AS AT 15/12/2004: When oral therapy is not feasible, and the strength, form and route of administration of the drug reasonably lend the preparation to the treatment of the condition, SOLU-CORTEF powder for injection is indicated for intravenous or intramuscular use in the following conditions: 1. ENDOCRINE DISORDERS: Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogues may be used in conjunction with mineralcorticoids where applicable; in infancy, mineralcorticoid supplementation is of particular importance). Acute adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; mineralcorticoid supplements may be necessary, particularly when synthetic analogues are used). Preoperatively and in the event of serious trauma or illness, in patients with known adrenal insufficiency or when adrenocortical reserve is doubtful. Shock unresponsive to conventional therapy if adrenocortical insufficiency exists or is suspected. Congenital adrenal hyperplasia. Nonsuppurative thyroiditis. Hypercalcaemia associated with cancer. RHEUMATIC DISORDERS: As an adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Post-traumatic osteoarthritis. Synovitis of osteoarthritis. Rheumatoid arthritis, including juvenile arthritis (selected cases may require low-dose maintenance therapy). Acute and subacute bursitis. Epicondylitis. Acute non-specific tenosynovitis. Acute gouty arthritis. Psoriatic arthritis. Ankylosing spondylitis. COLLAGEN DISEASES: During an exacerbation or as maintenance therapy in selected cases of: Systematic lupus erythematosus. Systematic dermatomyositis (polymyositis). Acute rheumatic carditis. DERMATOLOGICAL DISEASES: Pemphigus. Severe erythema multiforme (Stevens-Johnson Syndrome). Exfoliative dermatitis. Bullous dermatitis herpetiformis. Severe seborrhoeic dermatitis. Severe psoriasis. Mycosis fungoides. ALLERGIC STATES: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in: Bronchial asthma. Drug hypersensitivity reactions. Contact dermatitis. Urticarial transfusion reactions. Atopic dermatitis. Serum sickness. Seasonal or perennial allergic rhinitis. Acute non-infectious laryngeal oedema (adrenaline is the drug of first choice). OPTHALMIC DISEASES: Severe acute and chronic allergic and inflammatory processes involving the eye, such as: Herpes zoster ophthalmicus. Iritis, iridocyclitis. Chorioretinitis. Diffuse posterior uveitis and choroiditis. Optic neuritis. Sympathetic ophthalmia. Anterior segment inflammation. Allergic conjunctivitis. Allergic corneal marginal ulcers. Keratitis. GASTROINTESTINAL DISEASES: To tide the patient over a critical period of the disease in : Ulcerative colitis (systemic therapy). Regional enteritis (systemic therapy). RESPIRATORY DISEASES: Symptomatic sarcoidosis. Loeffler's Syndrome not manageable by other means. Berylliosis. Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy. Aspiration pneumonitis. HAEMATOLOGICAL DISORERS: Acquired (autoimmune) haemolytic anaemia. Erythroblastopenia (RBC anaemia). Idiopathic thrombocytopenic purpura in adults (IV only; IM administration is contraindicated). Secondary thrombocytopenia in adults. Congenital (erythroid) hypoplastic anaemia. NEOPLASTIC DISEASES: For palliative management of: Leukaemia's and lymphomas in adults. Acute childhood leukaemia. OEDMATOUS STATES: To induce diuresis or remission of proteinuria in the nephrotic syndrome, without uraemia, of the idiopathic type or that due to lupus erythematosus. MISCELLANEOUS: Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy. Trichinosis with neurological or myocardial involvement.

How to take it

This medicine is a pack that contains more than one part.

Part 1: Diluent, not applicable

Clear colourless liquid

The way to take this medicine is: Intramuscular. This medicine is given through a needle inserted into the muscle beneath the skin.

Part 2: Injection, powder for

White freeze dried cake

The way to take this medicine is: Intramuscular. This medicine is given through a needle inserted into the muscle beneath the skin.

You should seek medical advice in relation to medicines and use only as directed by a healthcare professional.

Always read the label. If symptoms persist see your healthcare professional.

Storage instructions

Do I need a prescription?

This medicine is available from a pharmacist and requires a prescription. It is Schedule 4 : Prescription Only Medicine.

Is this medicine subsidised?

This medicine was verified as being available on the PBS (Pharmaceutical Benefits Scheme) on March 1, 2021. To learn more about this subsidy, visit the Pharmaceutical Benefits Scheme (PBS) website.

Consumer Medicines Information (CMI)

For side effects, taking other medicines and more

Print the CMI.

Listen to the CMI.


Reporting side effects

You can help ensure medicines are safe by reporting the side effects you experience.

You can report side effects to your doctor, or directly at www.tga.gov.au/reporting-problems

Back to top back to top

Healthdirect 24hr 7 days a week hotline

24 hour health advice you can count on

1800 022 222

Government Accredited with over 140 information partners

We are a government-funded service, providing quality, approved health information and advice

Australian Government, health department logo ACT Government logo New South Wales government, health department logo Northen Territory Government logo Government of South Australia, health department logo Tasmanian government logo Government of Western Australia, health department logo