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Active ingredients: spironolactone
What it is used for
Essential hypertension; oedematous disorders such as oedema and ascites of congestive cardiac failure, cirrhosis of the liver, nephrotic syndrome; diagnosis and treatment of primary hyperaldosteronism; as adjunctive therapy in malignant hypertension; in diuretic induced hypokalaemia when other measures are considered inappropriate or inadequate; prophylaxis of hypokalaemia in patients taking digitalis when other measures are considered inadequate or inappropriate, hirsutism. Essential Hypertension: ALDACTONE, when used alone, is effective in lowering both systolic and diastolic blood pressure. ALDACTONE improves the hypotensive action of thiazide diuretics while at the same time reducing or preventing potassium loss due to the thiazide. ALDACTONE enhances the effectiveness of other antihypertensive agents such as beta blockers, vasodilators etc. Congestive Cardiac Failure: ALDACTONE, when used alone, is effective in the management of oedema and sodium retention associated with congestive cardiac failure. ALDACTONE may be used in combination with a thiazide or other conventional diuretics for achieving diuresis in patients whose oedema is resistant to a thiazide or other conventional diuretics. Unlike conventional diuretics ALDACTONE does not produce hypokalaemia. When administered with a thiazide or other conventional diuretics ALDACTONE offsets hypokalaemia induced by these diuretics. The prevention of potassium loss is particularly important in the treatment of digitalized patients since digitalis intoxication may be precipitated if hypokalaemia is induced by conventional diuretic therapy. Hepatic Cirrhosis with Ascites and Oedema: ALDACTONE when used alone is frequently adequate for the relief of ascites and oedema associated with hepatic cirrhosis. ALDACTONE provides a mild and even diuresis and prevents excessive potassium excretion caused by thiazide diuretics thus avoiding possible precipitation of hepatic coma. Nephrotic Syndrome : Although glucocorticoids, whose anti inflammatory activity appears to benefit the primary pathologic process in the renal glomerulus, should probably be employed first, ALDACTONE either alone or in combination with a conventional diuretic is useful for inducing diuresis. Primary Hyperaldosteronism: ALDACTONE may be used to establish the diagnosis of primary hyperaldosteronism by therapeutic trial. ALDACTONE may also be used for the short term pre operative treatment of patients with primary hyperaldosteronism, long term maintenance therapy for patients with discrete aldosterone producing adrenal adenomas who are judged to be poor operative risks (or who decline surgery), and the long term maintenance therapy for patients with bilateral micro or macronodular adrenal hyperplasia (idiopathic hyperaldosteronism). Hirsutism in Females: ALDACTONE is effective in the treatment of females with hirsutism, an androgen related increase in facial and body hair. A reduction in hair growth, hair shaft diameter and hair pigmentation is seen. Use of Aldactone should be considered only after all other alternatives of non drug therapy have been explored. For women of child bearing age, see CONTRAINDICATIONS and PRECAUTIONS, Use in Pregnancy.
How to take it
The way to take this medicine is: Oral. This medicine is taken by mouth.
- Store below 30 degrees Celsius
- Shelf lifetime is 5 Years.
You should seek medical advice in relation to medicines and use only as directed by a healthcare professional.
Always read the label. If symptoms persist see your healthcare professional.
Round, buff-coloured film-coated tablet engraved "SEARLE" over "134" on one side and plain on the reverse, with peppermint odour.
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Do I need a prescription?
This medicine is available from a pharmacist and requires a prescription. It is
Is this medicine subsidised?
This medicine was verified as being available on the PBS (Pharmaceutical Benefits Scheme) on March 1, 2019. To learn more about this subsidy, visit the Pharmaceutical Benefits Scheme (PBS) website.
This medicine contains the active ingredients:
If you are over 65 years of age, there may be specific risks and recommendations for use of this medicine. Please discuss your individual circumstances with your pharmacist, doctor or health professional. For more information read our page on medication safety for older people.
Pregnant or planning a pregnancy?
For the active ingredient spironolactone
You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy.
For side effects, taking other medicines and more
Download consumer medicine information leaflet (pdf) from the Therapeutic Goods Administration (TGA) website
Reporting side effects
You can help ensure medicines are safe by reporting the side effects you experience.
You can report side effects to your doctor, or directly at www.tga.gov.au/reporting-problems
Hormonal treatments - All About Acne
The All About Acne team are a group of health and medical experts who have an interest in the management of acne. They include several dermatologists, a psychiatrist, a pharmacist and a cosmetic medical practitioner. These people donate their time and expertise in order to provide the most up-to-date, practical and relevant information on acne-related matters. All dermatologists on the All About Acne team are Fellows of the Australasian College of Dermatologists.
Read more on All About Acne website
Hirsutism in women - myDr.com.au
Hirsutism is the problem of having too much hair on the face or body. In women with hirsutism, the hair is course and pigmented and grows in areas where men tend to grow hair.
Read more on myDr website
Polycystic ovary syndrome - PCOS
Polycystic ovary syndrome (PCOS) is a condition that affects females in their reproductive years. It may cause irregular periods, excess hair growth and cysts on the ovaries.
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Mastalgia or breast pain isa common symptomencountered by women andmay be due to normal changes in hormone levels or due to certain diseases.
Read more on myVMC – Virtual Medical Centre website
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Find out the physical and psychological causes of impotence, also called erectile dysfunction or ED.
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If you have high blood pressureyour doctor may recommendlifestyle measures,such as diet and exercise, and possibly alsomedicines to control your blood pressure. Find out about
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Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne | Cochrane
The evidence suggests a lack of evidence to show whether spironolactone can reduce hirsutism and acne. Hirsutism in women (excessive hair growth) is most often caused by an increased production of male hormones. Spironolactone (`Aldactone' or `Spirotone') is an anti-androgen, which can be taken with or without the oral contraceptive pill to try and reduce hirsutism. From the studies included in this review, there is some evidence to show that spironolactone is an effective treatment to decrease the degree of hirsutism, but insufficient evidence for the management of acne vulgaris. It appears to be more effective than finasteride 5mg/day, metformin and low dose cyproterone acetate.
Read more on Cochrane (Australasian Centre) website