Rybrevant SC™
Active ingredients: Amivantamab
Consumer medicine information
For more information about CMIs and how to read them, please visit How to read Consumer Medicine Information (CMI).
What this medicine is used for
RYBREVANT SC is indicated:, in combination with lazertinib for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R substitution mutations, in combination with carboplatin and pemetrexed for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal-growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R substitution mutations, whose disease has progressed on or after treatment with an EGFR tyrosine kinase inhibitor (TKI), in combination with carboplatin and pemetrexed for the first-line treatment of adult patients with locally advanced or metastatic NSCLC with activating EGFR exon 20 insertion mutations, as monotherapy for the treatment of adult patients with locally advanced or metastatic NSCLC with activating EGFR exon 20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy
Source: ARTG
Storage conditions
- Shelf lifetime is 24 Months
- Store at 2 to 8 degrees Celsius
- Protect from Light; Do not Freeze; Refrigerate; Store in Original Container
Source: ARTG
How to use this medicine
Non-composite pack
This medicine contains one component only.
Component
- Injection, solution
- Subcutaneous
- Colourless to pale yellow preservative-free solution.
Source: ARTG
Do I need a prescription?
These medicine packs are available from a pharmacist and requires a prescription. It is Schedule 4: Prescription Only Medicine.
- 1
Source: ARTG
Is this medicine subsidised?
This medicine is not listed on the Pharmaceutical Benefits Scheme (PBS). Talk to your pharmacist about how much it will cost.
Source: PBS
Pregnant or planning a pregnancy?
For the active ingredient: Amivantamab
You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy.
Source: AHT
Data sources
- Australian Health Thesaurus (AHT) (Opens in new tab) – Last updated on 3 August 2026
- Australian Medicines Terminology (AMT) (Opens in new tab) – Last updated on 3 August 2026
- Australian Register of Therapeutic Goods (ARTG) (Opens in new tab) – Last updated on 3 August 2026
- Pharmaceutical Benefits Scheme (PBS) (Opens in new tab) – Last updated on 3 August 2026
- Medicines Information Pty Ltd (Opens in new tab) – Last updated on 4 March 2026
Disclaimer
Healthdirect medicines information is not intended for use in an emergency. If you are suffering an acute illness, overdose, or emergency condition, call triple zero (000) and ask for an ambulance.
Reasonable care has been taken to provide accurate information at the time of creation. This information is not intended to substitute medical advice, diagnosis or treatment and should not be exclusively relied on to manage or diagnose a medical condition. Please refer to our terms and conditions (Opens in new tab).
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