Aplidin™
Active ingredients: plitidepsin
Pack: Aplidin (1 x 2 mg vial, 1 x 4 mL inert diluent ampoule), 1 pack
Consumer medicine information
For more information about CMIs and how to read them, please visit How to read Consumer Medicine Information (CMI).
What this medicine is used for
Aplidin, in combination with dexamethasone, is indicated for the treatment of patients with relapsed and refractory multiple myeloma who have received at least three prior treatment regimens, including both a proteasome inhibitor and an immunomodulator. Aplidin may be used after two prior lines of therapy if refractory and/or intolerant to both a proteasome inhibitor and an immunomodulator.
Source: ARTG
Storage conditions
- Shelf lifetime is 60 Months
- Store at 2 to 8 degrees Celsius
- Protect from Light; Do not Freeze; Refrigerate
Source: ARTG
How to use this medicine
Composite pack
This medicine is a pack that contains more than one component.
Important: The components listed below are not necessarily in order of use. Please refer to the Consumer Medicine Information (CMI) or consult your doctor for proper administration instructions and sequence.
Component
- Injection, solution
- Intravenous Infusion
- Clear, slightly viscous liquid free of visible particles
Component
- Injection, intravenous infusion
- Intravenous Infusion
- The powder is a white to off-white power or solid cake
Source: ARTG
Do I need a prescription?
These medicine packs are available from a pharmacist and requires a prescription. It is Schedule 4: Prescription Only Medicine.
- 1 vial and ampoule in a single carton
Source: ARTG
Is this medicine subsidised?
This medicine is not listed on the Pharmaceutical Benefits Scheme (PBS). Talk to your pharmacist about how much it will cost.
Source: PBS
Pregnant or planning a pregnancy?
For the active ingredient: plitidepsin
You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy.
Source: AHT
Data sources
- Australian Health Thesaurus (AHT) (Opens in new tab) – Last updated on 3 August 2026
- Australian Medicines Terminology (AMT) (Opens in new tab) – Last updated on 3 August 2026
- Australian Register of Therapeutic Goods (ARTG) (Opens in new tab) – Last updated on 3 August 2026
- Pharmaceutical Benefits Scheme (PBS) (Opens in new tab) – Last updated on 3 August 2026
- Medicines Information Pty Ltd (Opens in new tab) – Last updated on 4 March 2026
Disclaimer
Healthdirect medicines information is not intended for use in an emergency. If you are suffering an acute illness, overdose, or emergency condition, call triple zero (000) and ask for an ambulance.
Reasonable care has been taken to provide accurate information at the time of creation. This information is not intended to substitute medical advice, diagnosis or treatment and should not be exclusively relied on to manage or diagnose a medical condition. Please refer to our terms and conditions (Opens in new tab).
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